How to make 'cold' tumours such as metastatic ocular melanoma more immunogenic?

Tony Ribas with a slide showing how we can improve t-cell infiltration on 'cold' tumours (i.e. those with few mutations such as ocular melanoma which consequently perform less well with PD-1 drugs).

The blue dots in the tumour indicate t-cell infiltration.

We can look at techniques such as Adoptive Cell Therapy, CAR T-cells and even targeting tumour escape mechanisms such as the tumour blood supply to make metastatic ocular melanoma tumours more 'immunogenic' (more visible & attractive to the immune system). Fascinating stuff.

Techniques to increase T-cell infiltration for 'cold' tumours such as ocular melanoma