Advocacy track - clinical trials

1. Running your own clinical trials.The myeloma clinical trials network

Management team formed by patients
funded trough FP7
6 millions euro
got the grant
communication is the key
unit, focus and persistence

2. Drugs repurposing, by Pan Panziarka

Rare disease - not interesting for pharma
The REDO project
International collaboration
Going back with searching 20-30 years, with the clearly understanding of how they are working
Repurposing drugs -faster and cheaper, we know already a lot about-
They are drugs for chronic conditions
e.g. Ketorolac in Breast cancer - incidental research showed that women using Ketorolac were doing better.

Search retrospectively and put the drug in trial prospectively
In angiosarcoma -propranolol showed efficacy
130 of drugs show evidence of working in cancer
Cimetidine - Cochrane reviews -show efficacy as adjuvant treatment in colorectal cancer;
Aspirin in colorectal cancer

Patient view: efficacy is the FIRST!!
Non commercial trials -should have their role
Rare disease -uninteresting for pharma companies
influence the decision makers to support repurposing drugs
Looking to generics
- no support from pharma or generic companies

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